A patient’s methylprednisolone IV dosage has been increased to 100 mg BID from 60 mg BID. What is the new total volume needed for one dose from a vial containing 125 mg per 1 cc?

To determine the new total volume needed for one dose of methylprednisolone, we start with the new dosage of 100 mg. The concentration of the vial is 125 mg per 1 cc.

To find out how many cc (cubic centimeters) are needed for a 100 mg dose, we use the following formula:

[

\text{Volume (cc)} = \frac{\text{Dose (mg)}}{\text{Concentration (mg/cc)}}

]

Substituting in the values:

[

\text{Volume (cc)} = \frac{100 \text{ mg}}{125 \text{ mg/cc}} = 0.8 \text{ cc}

]

Thus, for a dose of 100 mg, you would need 0.8 cc from the vial. Since the question asks for the total volume needed for one dose, 0.8 cc is the correct and final answer.

It's important to check that the answer reflects the required volume based on the concentration provided, ensuring the math aligns with dosage forms regularly used in pharmacy settings.